Ponoko offers laser cutting of materials based on design templates, and a supporting market place to sell your designs. If you sign up for a Prime account, they will also source local materials and work with you.
An article on Wired mentioned eMachineShop, which is a more traditional "upload your CAD files" prototyping shop.
TechShop in San Francisco is a machine shop operated like a Health Club: monthly membership, access to all kinds of CNCs, laser cutters, vacuum formers...cool stuff!
Shapeways offers 3D printing, using plastic materials.
Materialise.com is another more technical service, like eMachineShop.
Customized Products
Cafe Press allows you to upload your artwork and customize mugs, calendars, t-shirts...